Extracellular potassium concentration defines neuronal bursting properties

Ion concentration dynamics as a mechanism for neuronal bursting.

We describe a simple conductance-based model neuron that includes intra- and extracellular ion concentration dynamics and show that this model exhibits periodic bursting. The bursting arises as the fast-spiking behavior of the neuron is modulated by the slow oscillatory behavior in the ion concentration variables and vice versa. By separating these time scales and studying the bifurcation struc...

Neuronal interactions mediated by neurally evoked changes in the extracellular potassium concentration.

Neuronal interactions mediated by alteration of the extracellular K+ concentration [K+]o occur between populations as well as among single neurones in very restricted regions. The interactions mediated by K+ ions may range from low efficacy ones (in which the effects of increased [K+]o around the non-active cells can be recorded only after massive activity of a large population of neurones) to ...

Influence of the extracellular potassium concentration on the biophysical properties of KCNQ2, KCNQ3, and KCNQ5 voltage-gated potassium channels

A bistable membrane potential at low extracellular potassium concentration.

In order to understand the electrochemical behavior of a living cell at a low extracellular potassium concentration, a model is constructed. The model involves only the ATP driven sodium-potassium pump, and the sodium and potassium channels. Predictions of the model fit the N-shape of the current-voltage characteristic at low extracellular potassium. The model can, furthermore, quantitatively a...

Suppression of the hERG potassium channel response to premature stimulation by reduction in extracellular potassium concentration

Potassium channels encoded by human ether-à-go-go-related gene (hERG) mediate the cardiac rapid delayed rectifier K(+) current (IKr), which participates in ventricular repolarization and has a protective role against unwanted premature stimuli late in repolarization and early in diastole. Ionic current carried by hERG channels (IhERG) is known to exhibit a paradoxical dependence on external pot...